Scientific Papers

A Growing Compilation of the Important Research and Published Scientific Papers Related to Metabolic Health

Hit or Miss:The New Cholesterol Targets

Robert DuBroff, Aseem Malhotra, Michel de Lorgeril

Drug treatment to reduce cholesterol to new target levels is now recommended in four moderate to high-risk patient populations: patients who have already sustained a cardiovascular event, adult diabetic patients, individuals with low density lipoprotein cholesterol levels ≥190mg/ dL and individuals with an estimated 10-year cardiovascular risk ≥7.5%. Achieving these cholesterol target levels did not…

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Effects of the Low Carbohydrate, High Fat Diet on Glycemic Control and Body Weight in Patients With Type 2 Diabetes: Experience From a Community-Based Cohort

Shabina Roohi Ahmed, Sridevi Bellamkonda, Mihail Zilbermint, Jiangxia Wang, Rita Rastogi Kalyani

The optimal diet to improve glycemia in patients with type 2 diabetes remains unclear. Low carbohydrate, high fat (LCHF) diets can improve glycemic control, but have not been investigated in real-world settings.

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Treating binge eating and food addiction symptoms with low-carbohydrate Ketogenic diets: a case series

Matthew Carmen, Debra Lynn Safer, Laura R. Saslow, Tro Kalayjian, Ashley E. Mason, Eric C. Westman and Shebani Sethi Dalai

Report on the feasibility of a low-carbohydrate ketogenic diet initiated by three patients (age 54, 34, and 63) with obesity (average BMI 43.5 kg/m2) with comorbid binge eating and food addiction symptoms. All patients tolerated following the ketogenic diet (macronutrient proportion 10% carbohydrate, 30% protein, and 60% fat; at least 5040 kJ) for the prescribed…

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Impact Of Ketogenic Diet On Athletes: Current Insights

McSwiney FT, Doyle L, Plews DJ, Zinn C

The impact of a ketogenic diet (KD) (<50 g/d carbohydrate, >75% fat) on athletic performance has sparked much interest and self-experimentation in the past 3–4 years. Evidence shows 3–4-week adaptations to a KD in endurance-trained athletes were associated with maintenance of moderate (46–63% VO2max) and vigorous intensity (64–90% VO2max) endurance exercise

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Dietary fat guidelines have no evidence base: where next for public health nutritional advice?

Zoe Harcombe, PhD

Dietary fat guidelines have prevailed for almost 40 years. The evidence base at the time of their introduction has been examined for the first time and found lacking. Evidence currently available provides no additional support. Public health opinion differed when the guidelines were introduced. Opposition to the guidelines is becoming more strident. Substantial increases in diet-related…

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Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-year Non-randomized Clinical Trial

Shaminie J. Athinarayanan, Rebecca N. Adams, Sarah J. Hallberg, Amy L. McKenzie, Nasir H. Bhanpuri, Wayne W. Campbell, Jeff S. Volek, Stephen D. Phinney, James P. McCarter

An open label, non-randomized, controlled study with 262 and 87 participants with T2D were enrolled in the CCI and usual care (UC) groups, respectively.  Studies on long-term sustainability of low-carbohydrate approaches to treat diabetes are limited. The aim was to assess the effects of a continuous care intervention (CCI) on retention, glycemic control, weight, body…

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A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Mark T. Cucuzzella, Justin Tondt, Nancy E. Dockter, Laura Saslow, Thomas R. Wood

Metabolic syndrome has become a significant problem, with the American Diabetes Association estimating the cost of diabetes and pre-diabetes in the United States alone to be $322 billion per year. Numerous clinical trials have demonstrated the efficacy of low-carbohydrate diets in reversing metabolic syndrome and its associated disorders. This study was designed to examine how…

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A clinician’s guide to inpatient low carbohydrate diets for remission of type 2 diabetes : toward a standard of care protocol

Mark Cucuzzella, Adele Hite, Kaitlyn Patterson, Laura Saslow, Rory Heath

Type 2 diabetes (T2DM) is most often treated as a chronic progressive condition. However, both clinical experience and scientific studies have shown that remission indicated by a normalizing of blood glucose levels and safe medication reduction through lifestyle change should be considered an achievable clinical outcome for patients with T2DM. Dietary interventions that include therapeutic…

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LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

Michel de Lorgeril, David M Diamond, Rokuro Hama, Tomohito Hamazaki, Björn Hammarskjöld, Niamh Hynes, Malcolm Kendrick, Peter H Langsjoen, Luca Mascitelli, Kilmer S McCully, Harumi Okuyama ORCID Icon, Paul J Rosch, Tore Schersten, Sherif Sultan & Ralf Sundberg

For half a century, a high level of total cholesterol (TC) or low-density lipoprotein cholesterol (LDL-C) has been considered to be the major cause of atherosclerosis and cardiovascular disease (CVD), and statin treatment has been widely promoted for cardiovascular prevention. However, there is an increasing understanding that the mechanisms are more complicated and that statin…

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Type 1 diabetes mellitus successfully managed with the paleolithic ketogenic diet

Csaba Tóth, Zsófia Clemens

Diabetic patients are, generally, recommended to follow a diet that is low in fat and high in carbohydrates.  Clinical studies, conversely, showed metabolic benefits conferred by carbohydrate-restricted diets including the ketogenic diet and the paleolithic diet in type 2 diabetes.  Much less data on the use of low carbohydrate diets in type 1 diabetes (T1DM) are…

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